N,N-Dimethylethylenediamine → HCID 977703, compound

HRID 847792Notes

Reaction equation

HRID 847792 reaction equation
CS([C:5]1[NH:6][C:7]2[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=2[N:9]=1)(=O)=O.[CH3:14][N:15]([CH3:19])[CH2:16][CH2:17][NH2:18]>>[CH3:14][N:15]([CH3:19])[CH2:16][CH2:17][NH:18][C:5]1[NH:6][C:7]2[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=2[N:9]=1

Participants

3

Reactant 2

HCID 66053N,N-DimethylethylenediamineHCID 3035262-(methylsulfonyl)-1H-benzimidazole

Product 1

HCID 977703HCID 977703, compound

Procedure

27.2 G. (0.139 moles) of 2-methanesulfonyl benzimidazole and 26.5 g. (0.3 moles) of N,N-dimethylethylene diamine are combined and heated at 170°-175° C. for 5 hours. The mixture is then cooled and concentrated in vacuo. The residue is dissolved in methylene chloride washed with saturated sodium chloride, dried over sodium sulfate and evaporated to dryness affording 22 g. of N,N-dimethyl-N'-(2-benzimidazolyl)-1,2-ethane diamine compound which is recrystallized from benzene yielding 20.3 g. with a m.p. of 143.5-145.5.

Workup

  1. temperatureheated at 170°-175° C. for 5 hours
  2. temperatureThe mixture is then cooled
  3. concentrationconcentrated in vacuo
  4. dissolutionThe residue is dissolved in methylene chloride
  5. washwashed with saturated sodium chloride
  6. dry with materialdried over sodium sulfate
  7. customevaporated to dryness
  8. customaffording 22 g
  9. customof N,N-dimethyl-N'-(2-benzimidazolyl)-1,2-ethane diamine compound which is recrystallized from benzene yielding 20.3 g

Sources & evidence

ORD record
ord-f831274c0fe7442d9d96f3f47f5cd32a
Source dataset
uspto-grants-1981_10
Patent number
US04293703

Reaction notes

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