反应详情

温度

160 °C

A mixture of Compound 24 (2.55 g, 10.0 mmol) from step (a) of Example 27 and 1-4-butane sultone (2.98 g, 21.9 mmol) was heated in a pressure tube at 160° C. for 17 hours. The mixture was allowed to cool to room temperature, and the resulting mass was triturated with ethyl acetate (40 ml) until a pink solid separated. The solid was collected by centrifugation, washed with ethyl acetate and dried under vacuum to yield 3.58 g (92%) of Compound 26 with the structure:

1. temperatureto cool to room temperature
2. customthe resulting mass was triturated with ethyl acetate (40 ml) until a pink solid
3. customseparated
4. customThe solid was collected by centrifugation
5. washwashed with ethyl acetate
6. customdried under vacuum