1,3-Propanediamine → N-(3-aminopropyl)pyrimidin-2-amine

HRID 847867Notes

Reaction equation

HRID 847867 reaction equation
Br[C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[NH2:8][CH2:9][CH2:10][CH2:11][NH2:12].[O-]CC.[Na+]>C(O)C>[NH2:8][CH2:9][CH2:10][CH2:11][NH:12][C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 4281,3-PropanediamineHCID 783452-BromopyrimidineHCID 2723922Sodium ethoxide

Product 1

HCID 14397405N-(3-aminopropyl)pyrimidin-2-amine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Reaction of 2-bromopyrimidine with 1,3-diaminopropane in ethanol containing sodium ethoxide gives 2-(3-aminopropylamino)pyrimidine which on reaction with methyl isothiocyanate results in the production of N-methyl-N'-[3-(2-pyrimidylamino)propyl]thiourea.

Sources & evidence

ORD record
ord-b51f003eb8ef4c75a073dbf28f2aea17
Source dataset
uspto-grants-1981_10
Patent number
US04293697

Reaction notes

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