Aluminium lithium hydride → HCID 178519987, compound

HRID 847954Notes

Reaction equation

HRID 847954 reaction equation
[OH:1][C:2]1[C:3]([C:8](O)=[O:9])=[N:4][CH:5]=[CH:6][N:7]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[OH:1][C:2]1[C:3]([CH2:8][OH:9])=[N:4][CH:5]=[CH:6][N:7]=1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 178524895HCID 178524895, compound

Product 1

HCID 178519987HCID 178519987, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

3-Hydroxypyrazine-2-carboxylic acid is converted to the methyl ester and the ester is reduced with lithium aluminium hydride in tetrahydrofuran to give 3-hydroxy-2-hydroxymethylpyrazine. Treatment of 3-hydroxy-2-hydroxymethylpyrazine at room temperature with thionyl chloride gives 3-hydroxy-2-chloromethylpyrazine and reacting this intermediate with cysteamine by the procedure of Example 62 gives 2-[(2-aminoethyl)thiomethyl]-3-hydroxypyrazine.

Sources & evidence

ORD record
ord-5d17e2494f8043cbaf7a25d308a948bf
Source dataset
uspto-grants-1981_10
Patent number
US04293699

Reaction notes

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