1,3-Propanediamine → 2-(3-Aminopropylamino)pyrazine

HRID 847970Notes

Reaction equation

HRID 847970 reaction equation
Cl[C:2]1[CH:7]=[N:6][CH:5]=[CH:4][N:3]=1.[NH2:8][CH2:9][CH2:10][CH2:11][NH2:12].[O-]CC.[Na+]>C(O)C>[NH2:8][CH2:9][CH2:10][CH2:11][NH:12][C:2]1[CH:7]=[N:6][CH:5]=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 4281,3-PropanediamineHCID 73277ChloropyrazineHCID 2723922Sodium ethoxide

Product 1

HCID 143974072-(3-Aminopropylamino)pyrazine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Reacting 2-chloropyrazine with 1,3-diaminopropane in ethanol containing sodium ethoxide by the procedure of Example 89 gives 2-(3-aminopropylamino)pyrazine.

Sources & evidence

ORD record
ord-f7b6c517c5a94ee598645b43a6be7b5b
Source dataset
uspto-grants-1981_10
Patent number
US04293699

Reaction notes

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