1,3-Propanediamine → HCID 178511125, compound

HRID 848013Notes

Reaction equation

HRID 848013 reaction equation
Cl[C:2]1[N:6]=[CH:5][NH:4][N:3]=1.[NH2:7][CH2:8][CH2:9][CH2:10][NH2:11].[O-]CC.[Na+]>C(O)C>[NH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:2]1[N:6]=[CH:5][NH:4][N:3]=1

Participants

5

Reactant 3

HCID 4281,3-PropanediamineHCID 2723922Sodium ethoxideHCID 178478410HCID 178478410, compound

Product 1

HCID 178511125HCID 178511125, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 3-chloro-1,2,4-triazole (10.3 g., 0.1 m.) and 1,3-diaminopropane (7.4 g, 0.1 m.) in ethanol containing sodium ethoxide is allowed to stand overnight. The solvent is removed to give 3-(3-aminopropylamino)-1,2,4-triazole and this intermediate is reacted with dimethyl-N-cyanoimidodithiocarbonate and methylamine by the procedure of Example 3(d) to give N-cyano-N'-methyl-N"-[3-(3-(1,2,4-triazolyl)amino)propyl]guanidine.

Workup

  1. customThe solvent is removed

Sources & evidence

ORD record
ord-73dfd61b40bd47a4837dd1584b4d0d0d
Source dataset
uspto-grants-1981_10
Patent number
US04293699

Reaction notes

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