HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trichloroacetic Acid → Methyl 1-methyl-5-(cyanohydroxyphenylmethyl)pyrrole-2-acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trichloroacetic Acid | HCID 6421 | — |
| Reactant | Phenylglyoxylonitrile | HCID 11953 | — |
| Reactant | Methyl 1-methylpyrrol-2-acetate | HCID 103992 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | Methyl 1-methyl-5-(cyanohydroxyphenylmethyl)pyrrole-2-acetate | HCID 12940094 | — |
Reaction Steps
A solution of 6.7 g (0.05 mole) of benzoylcyanide, 7.6 g (0.05 mole) of methyl 1-methylpyrrole-2-acetate and 0.2 g of trichloroacetic acid in 20 ml. of ether was stirred for four days at 25° C. under argon. The solution was cooled to 0° and the solid methyl 5-(cyanohydroxyphenylmethyl)-1-methylpyrrole-2-acetate was collected by filtration; mp 148°-153°, yield, 4.0 g (28 percent).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04294760 |
| Source dataset | uspto-grants-1981_10 |
| ORD ID | ord-86409ac2f2464fd09f1ef5b712719c46 |
| Source note | uspto-grants-1981_10 |