反应详情

A solution of 6.7 g (0.05 mole) of benzoylcyanide, 7.6 g (0.05 mole) of methyl 1-methylpyrrole-2-acetate and 0.2 g of trichloroacetic acid in 20 ml. of ether was stirred for four days at 25° C. under argon. The solution was cooled to 0° and the solid methyl 5-(cyanohydroxyphenylmethyl)-1-methylpyrrole-2-acetate was collected by filtration; mp 148°-153°, yield, 4.0 g (28 percent).

1. temperatureThe solution was cooled to 0°
2. filtrationthe solid methyl 5-(cyanohydroxyphenylmethyl)-1-methylpyrrole-2-acetate was collected by filtration
3. custommp 148°-153°, yield