HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-Benzoyl-1-methylpyrrole-2-acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methyl 1-methyl-5-(cyanohydroxyphenylmethyl)pyrrole-2-acetate | HCID 12940094 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 5-Benzoyl-1-methylpyrrole-2-acetic acid | HCID 10263805 | 77% |
Reaction Steps
A suspension of 1.0 g of methyl 5-(cyanohydroxyphenylmethyl)-1-methylpyrrole-2-acetate in 20 ml of 5 percent sodium hydroxide solution was heated under reflux for 30 minutes. The solution was acidified with 3 N hydrochloric acid solution. The solid was collected and recrystallized from acetonitrile to give 0.61 g (77 percent yield) of white crystalline 5-benzoyl-1-methylpyrrole-2-acetic acid, mp 145°-6°, undepressed by admixture with authentic product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04294760 |
| Source dataset | uspto-grants-1981_10 |
| ORD ID | ord-7efaf7d2dd0b4b96a71f3cb97e4cfb3c |
| Source note | uspto-grants-1981_10 |