反应详情

A suspension of 1.0 g of methyl 5-(cyanohydroxyphenylmethyl)-1-methylpyrrole-2-acetate in 20 ml of 5 percent sodium hydroxide solution was heated under reflux for 30 minutes. The solution was acidified with 3 N hydrochloric acid solution. The solid was collected and recrystallized from acetonitrile to give 0.61 g (77 percent yield) of white crystalline 5-benzoyl-1-methylpyrrole-2-acetic acid, mp 145°-6°, undepressed by admixture with authentic product.

1. temperaturewas heated
2. temperatureunder reflux for 30 minutes
3. customThe solid was collected
4. customrecrystallized from acetonitrile