3-Chloro-N,N-dimethyl-1-propanamine → N,N-Dimethyl-3-{[oxo(phenyl)(thiophen-2-yl)-lambda~6~-sulfanylidene]amino}propan-1-amine

HRID 848066Notes

Reaction equation

HRID 848066 reaction equation
[C:1]1([S:7]([C:10]2[S:11][CH:12]=[CH:13][CH:14]=2)(=[NH:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:15][N:16]([CH3:21])[CH2:17][CH2:18][CH2:19]Cl>>[CH3:15][N:16]([CH3:21])[CH2:17][CH2:18][CH2:19][N:9]=[S:7]([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)([C:10]1[S:11][CH:12]=[CH:13][CH:14]=1)=[O:8]

Participants

3

Reactant 2

HCID 669603-Chloro-N,N-dimethyl-1-propanamineHCID 20566262HCID 20566262, compound

Product 1

HCID 3054391N,N-Dimethyl-3-{[oxo(phenyl)(thiophen-2-yl)-lambda~6~-sulfanylidene]amino}propan-1-amineYield 38%

Procedure

In a manner analogous to that described in Example 1, Stage 3, by the reaction of phenyl-(2-thienyl)-sulphoximide with 3-dimethylaminopropyl chloride, there is obtained, in a yield of 38% of theory, N-(3-dimethylaminopropyl)-S-phenyl-S-(2-thienyl)-sulphoximide, the fumarate of which, after recrystallisation from ethyl acetate/isopropanol, melts at 125° C.

Sources & evidence

ORD record
ord-4eda5d77d4434e1e9fcb088356b9abff
Source dataset
uspto-grants-1981_10
Patent number
US04294838

Reaction notes

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