Isopropylamine → Methyl 3-[(propan-2-yl)amino]propanoate

HRID 848071Notes

Reaction equation

HRID 848071 reaction equation
[C:1]([O:5][CH3:6])(=[O:4])[CH:2]=[CH2:3].[CH:7]([NH2:10])([CH3:9])[CH3:8]>>[CH:7]([NH:10][CH2:3][CH2:2][C:1]([O:5][CH3:6])=[O:4])([CH3:9])[CH3:8]

Participants

3

Reactant 2

HCID 6363IsopropylamineHCID 7294Methyl Acrylate

Product 1

HCID 12774812Methyl 3-[(propan-2-yl)amino]propanoateYield 84.9%

Procedure

8.6 g of methyl acrylate are added dropwise to 5.9 g of isopropylamine under ice-cooling and stirring. The mixture is further stirred at room temperature for 5 hours. Then, the reaction mixture is distilled under reduced pressure. 12.3 g of methyl 3-isopropylaminopropionate are thereby obtained as a colorless oil. Yield: 84.5%

Workup

  1. temperaturecooling
  2. stirringThe mixture is further stirred at room temperature for 5 hours
  3. distillationThen, the reaction mixture is distilled under reduced pressure

Sources & evidence

ORD record
ord-7dfae0682b68414e90c1265e1b945c02
Source dataset
uspto-grants-1981_10
Patent number
US04294832

Reaction notes

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