反应详情

2-Amino-9-(2-hydroxyethoxymethyl)adenine (0.25 g) was dissolved in hot ethanol (50 ml) and the solution cooled in an ice bath. To the cool solution was added sufficient HCl-saturated ethanol to give a pH of 1.0. Dry ether (50 ml) was then added and the mixture thoroughly chilled. The resulting flesh-colored solid was removed by filtration and washed with cold ethanol. Recrystallization from methanol yielded 2-amino-9-(2-hydroxyethoxymethyl)adenine hydrochloride (0.21 g., 74% of theoretical), m.p. 207°-211° C. Elemental analysis and NMR support this structure.

1. temperaturethe solution cooled in an ice bath
2. customto give a pH of 1.0
3. temperaturethe mixture thoroughly chilled
4. customThe resulting flesh-colored solid was removed by filtration
5. washwashed with cold ethanol
6. customRecrystallization from methanol