Ethyl 2-bromo-2-phenylpropanoate → 2-(6-Ethoxybenzothiazol-2-ylthio)-2-phenylpropionic acid ethyl ester

HRID 848108Notes

Reaction equation

HRID 848108 reaction equation
[CH2:1]([O:3][C:4]1[CH:13]=[CH:12][C:7]2[N:8]=[C:9]([SH:11])[S:10][C:6]=2[CH:5]=1)[CH3:2].[CH2:14]([O:16][C:17](=[O:27])[C:18](Br)([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH3:19])[CH3:15]>C(O)C>[CH2:14]([O:16][C:17](=[O:27])[C:18]([S:11][C:9]1[S:10][C:6]2[CH:5]=[C:4]([O:3][CH2:1][CH3:2])[CH:13]=[CH:12][C:7]=2[N:8]=1)([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH3:19])[CH3:15]

Participants

4

Reactant 2

HCID 3778911Ethyl 2-bromo-2-phenylpropanoateHCID 178466040HCID 178466040, compound

Product 1

HCID 129283922-(6-Ethoxybenzothiazol-2-ylthio)-2-phenylpropionic acid ethyl ester

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2.3 g of Na is dissolved in 80 ml of ethanol; 21.1 g of 6-ethoxy-2-mercaptobenzothiazole is added and the mixture is stirred until solution takes place. 25.7 g of 2-bromo-2-phenylpropionic acid ethyl ester is then added and the mixture is stirred overnight at 20° and worked up in the customary manner to give 2-(6-ethoxybenzothiazol-2-ylthio)-2-phenylpropionic acid ethyl ester, m.p. 92°-94°.

Workup

  1. stirringthe mixture is stirred overnight at 20°

Sources & evidence

ORD record
ord-5c0abd857c1c4d749eae13239a2f515f
Source dataset
uspto-grants-1981_10
Patent number
US04294839

Reaction notes

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