Ethyl 2-bromo-2-phenylpropanoate → 2-(6-Ethoxybenzothiazol-2-ylthio)-2-phenylpropionic acid ethyl ester

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Reaction Steps

2.3 g of Na is dissolved in 80 ml of ethanol; 21.1 g of 6-ethoxy-2-mercaptobenzothiazole is added and the mixture is stirred until solution takes place. 25.7 g of 2-bromo-2-phenylpropionic acid ethyl ester is then added and the mixture is stirred overnight at 20° and worked up in the customary manner to give 2-(6-ethoxybenzothiazol-2-ylthio)-2-phenylpropionic acid ethyl ester, m.p. 92°-94°.

Provenance & Evidence