Potassium Hydroxide → Tazasubrate

HRID 848111노트

반응식

HRID 848111 반응식
C([O:3][C:4](=[O:26])[C:5]([S:13][C:14]1[S:15][C:16]2[CH:22]=[C:21]([O:23][CH2:24][CH3:25])[CH:20]=[CH:19][C:17]=2[N:18]=1)([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH3:6])C.[OH-].[K+]>C(O)C>[CH2:24]([O:23][C:21]1[CH:20]=[CH:19][C:17]2[N:18]=[C:14]([S:13][C:5]([C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=3)([CH3:6])[C:4]([OH:26])=[O:3])[S:15][C:16]=2[CH:22]=1)[CH3:25]

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 129283922-(6-Ethoxybenzothiazol-2-ylthio)-2-phenylpropionic acid ethyl ester

생성물 1

HCID 174749Tazasubrate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

6 g of 2-(6-ethoxybenzothiazol-2-ylthio)-2-phenylpropionic acid ethyl ester and 6 g of KOH in 100 ml of ethanol are stirred at 20°; the mixture is evaporated; the residue is dissolved in water; and the solution is washed with ether, acidified with hydrochloric acid and extracted with CH2Cl2. The phases are separated and the organic phase is dried and evaporated to give 2-(6-ethoxybenzothiazol-2-ylthio)-2-phenylpropionic acid. M.p. 152°-153° (from CCl4).

후처리

  1. customthe mixture is evaporated
  2. dissolutionthe residue is dissolved in water
  3. washand the solution is washed with ether
  4. extractionextracted with CH2Cl2
  5. customThe phases are separated
  6. customthe organic phase is dried
  7. customevaporated

출처 및 근거

ORD 기록
ord-9e18616d8c23471e9f13d90026eeb3b5
출처 데이터셋
uspto-grants-1981_10
특허 번호
US04294839

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