Fluorobenzene → 3-(1-Benzoyl 4-piperidyl) 1-(4-fluorophenyl) 1-propanone

HRID 848156Notes

Reaction equation

HRID 848156 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:8]([N:16]1[CH2:21][CH2:20][CH:19]([CH2:22][CH2:23][C:24](O)=[O:25])[CH2:18][CH2:17]1)(=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>>[C:8]([N:16]1[CH2:21][CH2:20][CH:19]([CH2:22][CH2:23][C:24]([C:5]2[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=2)=[O:25])[CH2:18][CH2:17]1)(=[O:15])[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 10008FluorobenzeneHCID 191084543-(1-Benzoylpiperidin-4-yl)propanoic acid

Product 1

HCID 545157143-(1-Benzoyl 4-piperidyl) 1-(4-fluorophenyl) 1-propanoneYield 125.1%

Procedure

The procedure is as in Example 1, starting from 8.8 g of fluorobenzene instead of the 9.9 g of anisol and from 20 g instead of from 15.7 g of 3-(1-benzoyl 4-piperidyl) propionic acid. 25.5 g of crude 3-(1-benzoyl 4-piperidyl) 1-(4-fluorophenyl) 1-propanone in the form of an oil are obtained.

Sources & evidence

ORD record
ord-92c7f755c66c44fb925797974aa488e6
Source dataset
uspto-grants-1981_10
Patent number
US04294841

Reaction notes

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