HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichlorobenzene → 1-(3,4-Dichlorophenyl) 3-(1-benzoyl 4-piperidyl) 1-propanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichlorobenzene | HCID 7239 | — |
| Reactant | Anisole | HCID 7519 | — |
| Reactant | 3-(1-Benzoylpiperidin-4-yl)propanoic acid | HCID 19108454 | — |
| Product | 1-(3,4-Dichlorophenyl) 3-(1-benzoyl 4-piperidyl) 1-propanone | HCID 54459666 | — |
Reaction Steps
In Example 1 the 9.9 g of anisole and the 15.7 g of 3-(1-benzoyl 4-piperidyl) propionic acid are substituted by 185 ml of 1,2 dichlorobenzene and 35 g of 3-(1-benzoyl 4-piperidyl) propionic acid respectively. The reaction is effected at 100° C. and without solvent. 51.1 g of crude 1-(3,4-dichlorophenyl) 3-(1-benzoyl 4-piperidyl) 1-propanone in the form of an oil which crystallizes slowly are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04294841 |
| Source dataset | uspto-grants-1981_10 |
| ORD ID | ord-00dfe80d22d94c26b46ffe088526d577 |
| Source note | uspto-grants-1981_10 |