1,2-Dichlorobenzene → 1-(3,4-Dichlorophenyl) 3-(1-benzoyl 4-piperidyl) 1-propanone

HRID 848157Notes

Reaction equation

HRID 848157 reaction equation
C1(OC)C=CC=CC=1.[C:9]([N:17]1[CH2:22][CH2:21][CH:20]([CH2:23][CH2:24][C:25]([OH:27])=O)[CH2:19][CH2:18]1)(=[O:16])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[Cl:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[Cl:35]>>[Cl:28][C:29]1[CH:34]=[C:33]([C:25](=[O:27])[CH2:24][CH2:23][CH:20]2[CH2:19][CH2:18][N:17]([C:9](=[O:16])[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH2:22][CH2:21]2)[CH:32]=[CH:31][C:30]=1[Cl:35]

Participants

4

Reactant 3

HCID 72391,2-DichlorobenzeneHCID 7519AnisoleHCID 191084543-(1-Benzoylpiperidin-4-yl)propanoic acid2×

Product 1

HCID 544596661-(3,4-Dichlorophenyl) 3-(1-benzoyl 4-piperidyl) 1-propanone

Procedure

In Example 1 the 9.9 g of anisole and the 15.7 g of 3-(1-benzoyl 4-piperidyl) propionic acid are substituted by 185 ml of 1,2 dichlorobenzene and 35 g of 3-(1-benzoyl 4-piperidyl) propionic acid respectively. The reaction is effected at 100° C. and without solvent. 51.1 g of crude 1-(3,4-dichlorophenyl) 3-(1-benzoyl 4-piperidyl) 1-propanone in the form of an oil which crystallizes slowly are obtained.

Workup

  1. customis effected at 100° C. and without solvent
  2. custom51.1 g of crude 1-(3,4-dichlorophenyl) 3-(1-benzoyl 4-piperidyl) 1-propanone in the form of an oil which crystallizes slowly
  3. customare obtained

Sources & evidence

ORD record
ord-00dfe80d22d94c26b46ffe088526d577
Source dataset
uspto-grants-1981_10
Patent number
US04294841

Reaction notes

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