Hydrochloric Acid → 4-[3-(3,4-Dichlorophenyl)1-propyl]piperidine

HRID 848160Notes

Reaction equation

C([N:9]1[CH2:14][CH2:13][CH:12]([CH2:15][CH2:16][C:17]([C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[C:21]([Cl:26])[CH:20]=2)=O)[CH2:11][CH2:10]1)(=O)C1C=CC=CC=1.Cl>>[Cl:26][C:21]1[CH:20]=[C:19]([CH2:17][CH2:16][CH2:15][CH:12]2[CH2:13][CH2:14][NH:9][CH2:10][CH2:11]2)[CH:24]=[CH:23][C:22]=1[Cl:25]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 544596661-(3,4-Dichlorophenyl) 3-(1-benzoyl 4-piperidyl) 1-propanone

Product 1

HCID 30590264-[3-(3,4-Dichlorophenyl)1-propyl]piperidineYield 42.9%

Procedure

The procedure is as in Example 6 starting from 51.1 g of 3-(1-benzoyl 4-piperidyl) 1-(3,4-dichlorophenyl) 1-propanone. 15.3 g of 4-[3-(3,4-dichlorophenyl)1-propyl]piperidine in the form of the hydrochloride melting at 150° C. are obtained.

Sources & evidence

ORD record: ord-5f045b61457746c685153167cc156d58
Source dataset: uspto-grants-1981_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04294841

Reaction notes

Loading…