Water → HCID 20566347, compound

HRID 848174Notes

Reaction equation

HRID 848174 reaction equation
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[NH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[S:13][CH2:14][C:15]1[N:19]=[CH:18][O:17][N:16]=1.O>N1C=CC=CC=1>[CH3:1][S:2]([NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[S:13][CH2:14][C:15]1[N:19]=[CH:18][O:17][N:16]=1)(=[O:4])=[O:3]

Participants

5

Reactant 3

HCID 962WaterHCID 31297Methanesulfonyl chlorideHCID 3057622Benzenamine, 2-((1,2,4-oxadiazol-3-ylmethyl)thio)-

Product 1

HCID 20566347HCID 20566347, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Methanesulphonyl chloride (1.39 g) was added dropwise to a cooled solution of 3-(2-aminophenylthiomethyl)-1,2,4-oxadiazole (3.1 g) in pyridine (12 ml). The reaction mixture was then poured into water (75 ml) the so formed solid removed by filtration and crystallised from ethanol to give 3-(2-methylsulphonamidophenylthiomethyl)-1,2,4-oxadiazole, m.p. 106°.

Workup

  1. customremoved by filtration
  2. customcrystallised from ethanol

Sources & evidence

ORD record
ord-7d0737f2ea4f42e69f5b2de7e77e5887
Source dataset
uspto-grants-1981_10
Patent number
US04294843

Reaction notes

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