Phenyl glycidyl ether → HCID 20566365, compound

HRID 848177Notes

Reaction equation

HRID 848177 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8][CH2:9][C:10]1[N:14]=[CH:13][O:12][N:11]=1.[O:15]1[CH:17]([CH2:18][O:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:16]1>>[OH:15][CH:17]([CH2:18][O:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH2:16][NH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8][CH2:9][C:10]1[N:14]=[CH:13][O:12][N:11]=1

Participants

3

Reactant 2

HCID 31217Phenyl glycidyl etherHCID 3057622Benzenamine, 2-((1,2,4-oxadiazol-3-ylmethyl)thio)-

Product 1

HCID 20566365HCID 20566365, compound

Procedure

A mixture of 3-(2-aminophenylthiomethyl)1,2,4-oxadiazole (2.07 g; 10-2 mol) and 1,2-epoxy-3-phenoxy propane (1.5 g; 10-2 mol) was warmed on a steam bath during 48 hours. The so produced mixture was chromatographed on silica gel, elution with diethyl ether/hexane (1:1) producing 2-hydroxy-1-[2-(1,2,4-oxadiazol-3-yl-methylthio)anilino]-3-phenoxypropane as a colourless oil.

Workup

  1. temperaturewas warmed on a steam bath during 48 hours
  2. customThe so produced mixture was chromatographed on silica gel, elution with diethyl ether/hexane (1:1)

Sources & evidence

ORD record
ord-5dd18a6e32de4b42a97e22bb18fc1e61
Source dataset
uspto-grants-1981_10
Patent number
US04294843

Reaction notes

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