反应详情

To a solution of 6-chloro-5-nitronicotinic acid in acetic acid (240 ml) was added iron (20 g) and the mixture was heated with stirring on a steam bath. After 11/2 hours, the mixture was filtered hot and washed with hot acetic acid. The filtrate was concentrated to dryness and the residue was treated with 10% NaOH, filtered and the pH adjusted to 2-3. The solid was filtered to yield 8.0 g (60% yield) of 5-amino-6-chloronicotinic acid.

1. temperaturethe mixture was heated
2. filtrationAfter 11/2 hours, the mixture was filtered hot
3. washwashed with hot acetic acid
4. concentrationThe filtrate was concentrated to dryness
5. additionthe residue was treated with 10% NaOH
6. filtrationfiltered
7. filtrationThe solid was filtered