Thionyl Chloride → 3-(Acetylthio)-2-(methylthio)propionic acid chloride

HRID 848449Notes

Reaction equation

HRID 848449 reaction equation
[C:1]([S:4][CH2:5][CH:6]([S:10][CH3:11])[C:7](O)=[O:8])(=[O:3])[CH3:2].S(Cl)([Cl:14])=O>>[C:1]([S:4][CH2:5][CH:6]([S:10][CH3:11])[C:7]([Cl:14])=[O:8])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 205396923-(Acetylthio)-2-(methylthio)propionic acid

Product 1

HCID 543411833-(Acetylthio)-2-(methylthio)propionic acid chloride

Procedure

The 3-(acetylthio)-2-(methylthio)propionic acid is refluxed in thionyl chloride for two hours. The reaction mixture is distilled to remove excess thionyl chloride and the product is distilled in vacuo to yield 3-(acetylthio)-2-(methylthio)propionic acid chloride.

Workup

  1. distillationThe reaction mixture is distilled
  2. customto remove excess thionyl chloride
  3. distillationthe product is distilled in vacuo

Sources & evidence

ORD record
ord-bd32fff80e9849688a264e32c4cdfb35
Source dataset
uspto-grants-1981_10
Patent number
US04296113

Reaction notes

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