Diazomethane → 1-[3-(acetylthio)-1-oxopropyl]-4-oxo-L-proline, methyl ester

HRID 848462Notes

Reaction equation

HRID 848462 reaction equation
[C:1]([S:4][CH2:5][CH2:6][C:7]([N:9]1[CH2:16][C:15](=[O:17])[CH2:14][C@H:10]1[C:11]([OH:13])=[O:12])=[O:8])(=[O:3])[CH3:2].[N+](=[CH2:20])=[N-]>CCOCC>[C:1]([S:4][CH2:5][CH2:6][C:7]([N:9]1[CH2:16][C:15](=[O:17])[CH2:14][C@H:10]1[C:11]([O:13][CH3:20])=[O:12])=[O:8])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 9550DiazomethaneHCID 127736631-[3-(Acetylthio)-1-oxopropyl]-4-oxo-L-proline

Product 1

HCID 127736751-[3-(acetylthio)-1-oxopropyl]-4-oxo-L-proline, methyl ester

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A solution of the product of Example 1 in ether is treated with a slight excess of diazomethane. After standing at room temperature for two hours, the solvent is evaporated to give 1-[3-(acetylthio)-1-oxopropyl]-4-oxo-L-proline, methyl ester.

Workup

  1. customthe solvent is evaporated

Sources & evidence

ORD record
ord-08edb3d9a03a43efba6bc25dad215ea7
Source dataset
uspto-grants-1981_10
Patent number
US04296113

Reaction notes

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