反应详情

A stirred solution of 15.3 g. of N-decyl-3-(2-nitrophenyl)propenamide in 200 ml. of glacial acetic acid was heated to 85° C. on a steam bath, and then 12.9 g. of iron powder was added portionwise, during 25 minutes. The reaction temperature was kept between 85° and 95° C. during the addition. The reaction mixture was filtered hot, and the residue was washed with hot glacial acetic acid. The cooled, combined acetic acid solutions were evaporated in vacuo, and the residue was dissolved in ethyl acetate. The ethyl acetate solution was washed several times with water and then with saturated sodium chloride solution. The resulting solution was dried using sodium sulfate, and then it was evaporated in vacuo to give the crude title product.

1. additionThe reaction temperature was kept between 85° and 95° C. during the addition
2. filtrationThe reaction mixture was filtered hot
3. washthe residue was washed with hot glacial acetic acid
4. customwere evaporated in vacuo
5. dissolutionthe residue was dissolved in ethyl acetate
6. washThe ethyl acetate solution was washed several times with water
7. customThe resulting solution was dried
8. customit was evaporated in vacuo