反应详情

温度

90 °C

60 g (0.3 mol) of 1,4-dihydroxy-2-naphthoic acid was added to 150 ml of 2-bromoethanol and, under heating at 90° C. with stirring, hydrogen chloride gas was bubbled into the mixture during a reaction period of 2 hours. The mixture was then cooled to from 10° to 20° C. and the crystals precipitated were collected by filtration to obtain 47.4 g (50% yield) of 1-hydroxy-4-(β-bromoethoxy)-2-naphthoic acid.

1. customhydrogen chloride gas was bubbled into the mixture during a reaction period of 2 hours
2. temperatureThe mixture was then cooled to from 10° to 20° C.
3. customthe crystals precipitated
4. filtrationwere collected by filtration