Chloride → HCID 20565714, compound

HRID 848581Notes

Reaction equation

HRID 848581 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[S:8][CH:9]=[C:10]([CH2:12][C:13]([NH2:15])=O)[N:11]=2)=[CH:3][CH:2]=1.[Cl-]>N1C=CC=CC=1>[N:1]1[CH:2]=[CH:3][C:4]([C:7]2[S:8][CH:9]=[C:10]([CH2:12][C:13]#[N:15])[N:11]=2)=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 312ChlorideHCID 13030826HCID 13030826, compound

Product 1

HCID 20565714HCID 20565714, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To 2-[2-(4-pyridyl)thiazol-4-yl]acetamide (2.19 g., 0.01 mole) in pyridine (30 ml.) is added gradually p-toluenesulfuryl chloride (1.91 g., 0.01 mole). After stirring for one hour the mixture is poured into excess ice-water to give the title compound.

Sources & evidence

ORD record
ord-26781e3c758447b7baac03635c3f5b16
Source dataset
uspto-grants-1981_10
Patent number
US04296237

Reaction notes

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