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HRID84860

反应详情

EQUATION

反应方程式

HRID 84860 的结构方程式

REACTANTS

反应物

1
结构：CC(C)(C)OC(=O)N[C@H]1CCCC[C@H]1Nc1cc(Nc2cc(-c3ccccc3)no2)c(C#N)cc1F
HCID86666162

未命名化合物

PRODUCTS

生成物

1
结构：N#Cc1cc(F)c(N[C@@H]2CCCC[C@@H]2N)cc1Nc1cc(-c2ccccc2)no1
HCID67776400

未命名化合物

收率 160.8%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O=C(O)C(F)(F)F
溶剂HCID6422

未命名化合物

PROCEDURE

实验过程

The compound tert-butyl (1S,2R)-2-(4-cyano-2-fluoro-5-(3-phenylisoxazol-5-ylamino)phenylamino)cyclohexylcarbamate (40 mg, 0.081 mmol) was dissolved in TFA (1.0 mL). After 20 min, TFA was removed in vacuo to give 4-((1R,2S)-2-aminocyclohexylamino)-5-fluoro-2-(3-phenylisoxazol-5-ylamino)benzonitrile (51 mg).

WORKUP

后处理

  1. customTFA was removed in vacuo