2,6-Dimethylaniline → HCID 70546412, compound

HRID 848693Notes

Reaction equation

HRID 848693 reaction equation
[C:1]([C:3](=[CH:12]OCC)[C:4]([NH:6][C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5])#[N:2].[CH3:16][C:17]1[CH:23]=[CH:22][CH:21]=[C:20]([CH3:24])[C:18]=1[NH2:19].CCCCCC>C(O)C>[C:1]([C:3](=[CH:12][NH:19][C:18]1[C:20]([CH3:24])=[CH:21][CH:22]=[CH:23][C:17]=1[CH3:16])[C:4]([NH:6][C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5])#[N:2]

Participants

5

Reactant 3

HCID 68962,6-DimethylanilineHCID 8058HexaneHCID 230015ethyl N-(2-cyano-3-ethoxyacryloyl)carbamate

Product 1

HCID 70546412HCID 70546412, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To α-cyano-β-ethoxy-N-ethoxycarbonylacrylamide (1.2 g), dissolved in about 5 ml of boiling ethanol, is added 0.6 g of 2,6-dimethylaniline. The reaction is refluxed for several hours and then hexane is added. On cooling, the reaction is filtered, and washed with ethanol and ether to give α-cyano-β-(2,6-dimethylanilino)-N-ethoxycarbonylacrylamide, m.p. 138°-140°.

Workup

  1. temperatureThe reaction is refluxed for several hours
  2. temperatureOn cooling
  3. filtrationthe reaction is filtered
  4. washwashed with ethanol and ether

Sources & evidence

ORD record
ord-eb8e599209d94aff81a6f04617dbe01c
Source dataset
uspto-grants-1981_10
Patent number
US04297297

Reaction notes

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