HCID 70546412, compound → HCID 13014421, compound

HRID 848694Notes

Reaction equation

HRID 848694 reaction equation
[C:1]([C:3](=[CH:12][NH:13][C:14]1[C:19]([CH3:20])=[CH:18][CH:17]=[CH:16][C:15]=1[CH3:21])[C:4]([NH:6][C:7](OCC)=[O:8])=[O:5])#[N:2]>CC1C=CC(C(C)C)=CC=1>[C:1]([C:3]1[C:4](=[O:5])[NH:6][C:7](=[O:8])[N:13]([C:14]2[C:19]([CH3:20])=[CH:18][CH:17]=[CH:16][C:15]=2[CH3:21])[CH:12]=1)#[N:2]

Participants

3

Reactant 1

HCID 70546412HCID 70546412, compound

Product 1

HCID 13014421HCID 13014421, compound

Reagents, catalysts & solvents 1

HCID 7463P-CymeneSolvent

Procedure

A mixture of α-cyano-β-(2,6-dimethylanilino)-N-ethoxycarbonylacrylamide (1.2 g) and about 10 ml of p-cymene is heated at reflux for about 1.5 hour. After cooling on standing, the crystalline product is collected by filtering and washing with ether to yield 5-cyano-1-(2,6-dimethylphenyl)uracil, m.p. 267°-269°.

Workup

  1. temperatureis heated
  2. temperatureat reflux for about 1.5 hour
  3. temperatureAfter cooling
  4. customthe crystalline product is collected
  5. filtrationby filtering
  6. washwashing with ether

Sources & evidence

ORD record
ord-ae5a8e8150e641f68942589431275530
Source dataset
uspto-grants-1981_10
Patent number
US04297297

Reaction notes

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