3-Fluoroaniline → HCID 70547182, compound

HRID 848700Notes

Reaction equation

HRID 848700 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].[C:9]([C:11](=[CH:20]OCC)[C:12]([NH:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[O:13])#[N:10]>>[C:9]([C:11](=[CH:20][NH:5][C:4]1[CH:6]=[CH:7][CH:8]=[C:2]([F:1])[CH:3]=1)[C:12]([NH:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[O:13])#[N:10]

Participants

3

Reactant 2

HCID 97423-FluoroanilineHCID 230015ethyl N-(2-cyano-3-ethoxyacryloyl)carbamate

Product 1

HCID 70547182HCID 70547182, compound

Procedure

3-Fluoroaniline (0.05 mol) is reacted with α-cyano-β-ethoxy-N-ethoxycarbonylacrylamide (0.05 mol) to yield α-cyano-β-(3-fluoroanilino)-N-ethoxycarbonylacrylamide, m.p. 169.5°-171.0°, which is heated at reflux in tetralin to yield 5-cyano-1-(3-fluorophenyl)uracil, m.p. 245.5°-246.5°.

Sources & evidence

ORD record
ord-abbda641fdcb4c4b9440402fe091f25f
Source dataset
uspto-grants-1981_10
Patent number
US04297297

Reaction notes

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