Hydrochloric Acid → 2-(3-carbamoylphenylamino)-N-(3,4-dimethoxyphenethyl)acetamide trihydrate

Participants

Reaction Steps

To 5.0 g of 2-(3-carbamoylphenylamino)-N-(3,4-dimethoxyphenethyl)acetamide hydrochloride was added 500 ml of water heated at 55° to 60° C. and the mixture was stirred while heating at the same temperature until the hydrochloride completely dissolved. After allowing the mixture to stand overnight, the crystals precipitated were collected by filtration, washed with water and air-dried by allowing to stand at room temperature for 10 days to obtain 4.2 g of 2-(3-carbamoylphenylamino)-N-(3,4-dimethoxyphenethyl)acetamide trihydrate as colorless needles having a melting point of 53.5°-55.5° C.

Provenance & Evidence