Hydrochloric Acid → 2-(3-carbamoylphenylamino)-N-(3,4-dimethoxyphenethyl)acetamide trihydrate

HRID 848732Notes

Reaction equation

HRID 848732 reaction equation
Cl.[C:2]([C:5]1[CH:6]=[C:7]([NH:11][CH2:12][C:13]([NH:15][CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[C:20]([O:26][CH3:27])[CH:19]=2)=[O:14])[CH:8]=[CH:9][CH:10]=1)(=[O:4])[NH2:3].Cl>O>[OH2:4].[OH2:4].[OH2:4].[C:2]([C:5]1[CH:6]=[C:7]([NH:11][CH2:12][C:13]([NH:15][CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[C:20]([O:26][CH3:27])[CH:19]=2)=[O:14])[CH:8]=[CH:9][CH:10]=1)(=[O:4])[NH2:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 156650Benzamide, 3-((2-((2-(3,4-dimethoxyphenyl)ethyl)amino)-2-oxoethyl)amino)-, monohydrochloride

Product 1

HCID 221497912-(3-carbamoylphenylamino)-N-(3,4-dimethoxyphenethyl)acetamide trihydrateYield 321.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 5.0 g of 2-(3-carbamoylphenylamino)-N-(3,4-dimethoxyphenethyl)acetamide hydrochloride was added 500 ml of water heated at 55° to 60° C. and the mixture was stirred while heating at the same temperature until the hydrochloride completely dissolved. After allowing the mixture to stand overnight, the crystals precipitated were collected by filtration, washed with water and air-dried by allowing to stand at room temperature for 10 days to obtain 4.2 g of 2-(3-carbamoylphenylamino)-N-(3,4-dimethoxyphenethyl)acetamide trihydrate as colorless needles having a melting point of 53.5°-55.5° C.

Workup

  1. temperatureheated at 55° to 60° C.
  2. dissolutioncompletely dissolved
  3. customthe crystals precipitated
  4. filtrationwere collected by filtration
  5. washwashed with water
  6. customair-dried
  7. waitto stand at room temperature for 10 days

Sources & evidence

ORD record
ord-13cae5ef6f70425ca242cc5392d03172
Source dataset
uspto-grants-1981_10
Patent number
US04297357

Reaction notes

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