Benzamide, 3-((2-((2-(3,4-dimethoxyphenyl)ethyl)amino)-2-oxoethyl)amino)-, monohydrochloride → 2-(3-carbamoylphenylamino)-N-(3,4-dimethoxyphenethyl)acetamide trihydrate

HRID 848733Notes

Reaction equation

HRID 848733 reaction equation
Cl.[C:2]([C:5]1[CH:6]=[C:7]([NH:11][CH2:12][C:13]([NH:15][CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[C:20]([O:26][CH3:27])[CH:19]=2)=[O:14])[CH:8]=[CH:9][CH:10]=1)(=[O:4])[NH2:3]>O>[OH2:4].[OH2:4].[OH2:4].[C:2]([C:5]1[CH:6]=[C:7]([NH:11][CH2:12][C:13]([NH:15][CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[C:20]([O:26][CH3:27])[CH:19]=2)=[O:14])[CH:8]=[CH:9][CH:10]=1)(=[O:4])[NH2:3]

Participants

3

Reactant 1

HCID 156650Benzamide, 3-((2-((2-(3,4-dimethoxyphenyl)ethyl)amino)-2-oxoethyl)amino)-, monohydrochloride

Product 1

HCID 221497912-(3-carbamoylphenylamino)-N-(3,4-dimethoxyphenethyl)acetamide trihydrateYield 337%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A suspension of 1 g of 2-(3-carbamoylphenylamino)-N-(3,4-dimethoxyphenethyl)acetamide hydrochloride in 20 ml of water was vigorously stirred, whereupon the mixture became a viscous liquid at once and subsequently crystals were formed again. After stirring was continued for 30 minutes, the crystals were collected by filtration, washed with water and then air-dried by allowing to stand at room temperature for 10 days to obtain 0.88 g of 2-(3-carbamoylphenylamino)-N-(3,4-dimethoxyphenethyl)acetamide trihydrate as a crystalline powder having a melting point of 51°-56° C.

Workup

  1. customwere formed again
  2. stirringAfter stirring
  3. filtrationthe crystals were collected by filtration
  4. washwashed with water
  5. customair-dried
  6. waitto stand at room temperature for 10 days

Sources & evidence

ORD record
ord-582567d9709b416082f49249fa8be3ce
Source dataset
uspto-grants-1981_10
Patent number
US04297357

Reaction notes

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