Benzamide, 3-((2-((2-(3,4-dimethoxyphenyl)ethyl)amino)-2-oxoethyl)amino)-, monohydrochloride → 2-(3-carbamoylphenylamino)-N-(3,4-dimethoxyphenethyl)acetamide trihydrate

Participants

Reaction Steps

A suspension of 1 g of 2-(3-carbamoylphenylamino)-N-(3,4-dimethoxyphenethyl)acetamide hydrochloride in 20 ml of water was vigorously stirred, whereupon the mixture became a viscous liquid at once and subsequently crystals were formed again. After stirring was continued for 30 minutes, the crystals were collected by filtration, washed with water and then air-dried by allowing to stand at room temperature for 10 days to obtain 0.88 g of 2-(3-carbamoylphenylamino)-N-(3,4-dimethoxyphenethyl)acetamide trihydrate as a crystalline powder having a melting point of 51°-56° C.

Provenance & Evidence