反应详情

To 3.0 g of 2-(3-carbamoylphenylamino)-N-(3,4-dimethoxyphenethyl)acetamide hydrochloride were added 20 ml of 5% aqueous sodium carbonate solution and 125 ml of chloroform and then the mixture was stirred at room temperature until the hydrochloride completely dissolved. The chloroform layer was separated, washed with water, dried and the solvent was concentrated to dryness under reduced pressure. The residue was crystallized from a mixture of methanol and diethyl ether to obtain 2.3 g of 2-(3-carbamoylphenylamino)-N-(3,4-dimethoxyphenethyl)acetamide having a melting point of 133° to 135° C.

1. dissolutioncompletely dissolved
2. customThe chloroform layer was separated
3. washwashed with water
4. customdried
5. concentrationthe solvent was concentrated to dryness under reduced pressure
6. customThe residue was crystallized from a mixture of methanol and diethyl ether