反应详情

While stirring, 15.2 g of N-2-butyl-N-methylamine is dripped into a solution of 22.4 g of α-chloro-α-(2,4-dichlorophenyl)-acetyl chloride (see a)) in 100 ml of dioxane. After the exothermic reaction has subsided, the mixture is stirred overnight and then poured into 700 ml of ice water; the resultant mixture is acidified with dilute hydrochloric acid and the oil which has precipitated is extracted 8 times, each time with 100 ml of dichloromethane. The extracts are combined, dried over magnesium sulfate and concentrated; there is obtained 17.2 g of α-chloro-α-(2,4-dichlorophenyl)-acetic acid-N-2-butyl-N-methyl amide as a colorless oil.

1. customAfter the exothermic reaction
2. stirringthe mixture is stirred overnight
3. customthe oil which has precipitated
4. extractionis extracted 8 times
5. dry with materialdried over magnesium sulfate
6. concentrationconcentrated