反应详情

The starting material is prepared as follows: A mixture of 3.7 g of N-acetyl-N',N'-dimethyl-thiourea and 7 g of 4-chloro-3-nitro-phenacyl bromide in 100 ml of isopropanol is refluxed for 2 hours, cooled and filtered. The residue is rendered basic and extracted with methylene chloride. The extract is dried and evaporated and the residue is recrystallised from a mixture of ethyl acetate and hexane, yielding 4-chloro-3-nitro-1-(4-methyl-2-dimethylamino-5-thiazoloyl)-benzene, which melts at 165°-169°.

1. customThe starting material is prepared
2. temperatureis refluxed for 2 hours
3. temperaturecooled
4. filtrationfiltered
5. extractionextracted with methylene chloride
6. customThe extract is dried
7. customevaporated
8. customthe residue is recrystallised from a mixture of ethyl acetate and hexane