HCID 10422857, compound → HCID 15411306, compound

HRID 849005Notes

Reaction equation

HRID 849005 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=1)[CH:16]=O.[NH2:21][C:22]1[CH:32]=[CH:31][C:25]2[NH:26][C:27](=[O:30])[CH2:28][S:29][C:24]=2[CH:23]=1>CCO>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=1)[CH:16]=[N:21][C:22]1[CH:32]=[CH:31][C:25]2[NH:26][C:27](=[O:30])[CH2:28][S:29][C:24]=2[CH:23]=1

Participants

4

Reactant 2

HCID 10422857HCID 10422857, compoundHCID 126274197-Amino-2H-1,4-benzothiazin-3(4H)-one

Product 1

HCID 15411306HCID 15411306, compoundYield 92.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A liquid mixture of 1.316 g (5 mmol) of 3-(2-quinolinylmethoxy)benzaldehyde, 0.901 g (5 mmol) of 7-amino-3,4-dihydro-2H-1,4-benzothiazin-3-one and 70 ml of EtOH was heated under reflux and stirring for 24 hours. The mixture was then allowed to cool down. The precipitate was collected by filtration, whereby 1.969 g of the title compound were obtained as pale yellow powder (yield: 92.3%).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux
  3. temperatureto cool down
  4. filtrationThe precipitate was collected by filtration

Sources & evidence

ORD record
ord-e84577f2fabb468f8c81768303a187d3
Source dataset
uspto-grants-2000_01
Patent number
US06011033

Reaction notes

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