Potassium Carbonate → HCID 11823434, compound

HRID 849010Notes

Reaction equation

HRID 849010 reaction equation
[CH2:1]([C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](=[O:13])[NH:5][N:4]=1)[CH3:2].Br[CH2:15][CH2:16][O:17][C:18]1[CH:25]=[CH:24][C:21]([CH:22]=[O:23])=[CH:20][CH:19]=1.C([O-])([O-])=O.[K+].[K+]>>[CH2:1]([C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](=[O:13])[N:5]([CH2:15][CH2:16][O:17][C:18]2[CH:25]=[CH:24][C:21]([CH:22]=[O:23])=[CH:20][CH:19]=2)[N:4]=1)[CH3:2]

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 2627064-(2-Bromoethoxy)BenzaldehydeHCID 51219084-ethyl-2H-phthalazin-1-one

Product 1

HCID 11823434HCID 11823434, compoundYield 54%

Procedure

##STR32## The title compound (450 mg, 54%) was prepared from 4-ethyl-1(2H)-phthalazinone (450 mg, 2.6 mmol) (Ref: Chemistry of Heterocyclic Compounds; Condensed Pyridazines including Cinnolines and Phthalazines, edited by R. N. Castle; John Wiley and Sons, 27, (1973) 375-441), 4-[2-bromoethoxy]benzaldehyde (600 mg, 2.6 mmol) and K2CO3 (720 mg, 5.2 mmol) by a similar procedure to that described in preparation 2. mp: 110° C.

Workup

  1. customthat described in preparation 2

Sources & evidence

ORD record
ord-df062644a3cb47bb87c3d1be8123c788
Source dataset
uspto-grants-2000_01
Patent number
US06011036

Reaction notes

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