Hydrochloric Acid → HCID 19369859, compound

HRID 849035Notes

Reaction equation

HRID 849035 reaction equation
[OH-].[Na+].C([O:6][C:7]1[C:8]([O:29][CH3:30])=[C:9]([O:27][CH3:28])[C:10]2[O:14][C:13]([CH2:16][CH2:17][CH2:18][CH2:19][C:20]([O:22]CC)=[O:21])([CH3:15])[CH2:12][C:11]=2[C:25]=1[CH3:26])(=O)C.Cl>CO>[OH:6][C:7]1[C:8]([O:29][CH3:30])=[C:9]([O:27][CH3:28])[C:10]2[O:14][C:13]([CH2:16][CH2:17][CH2:18][CH2:19][C:20]([OH:22])=[O:21])([CH3:15])[CH2:12][C:11]=2[C:25]=1[CH3:26]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 19369855HCID 19369855, compound

Product 1

HCID 19369859HCID 19369859, compoundYield 105.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

An aqueous 1N sodium hydroxide solution (30 ml) was added to a solution of ethyl 5-(5-acetoxy-2,3-dihydro-6,7-dimethoxy-2,4-dimethylbenzofuran-2-yl)valerate (2.3 g) in methanol (20 ml), and the mixture was stirred at room temperature for 2 hours. 1N hydrochloric acid was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain the title compound (2.0 g, 96%) as an oil.

Workup

  1. extractionthe mixture was extracted with ethyl acetate
  2. washThe extract was washed with saturated brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-7f3db60e39894535a490aaae37608a6e
Source dataset
uspto-grants-2000_01
Patent number
US06011046

Reaction notes

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