Oxonium, trimethyl-, tetrafluoroborate(1-) (1:1) → HCID 10560088, compound

HRID 849060Notes

Reaction equation

HRID 849060 reaction equation
[CH3:1][C@H:2]1[C@H:6]([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[NH:5][C:4](=[O:14])[CH2:3]1.F[B-](F)(F)F.[CH3:20][O+](C)C>C(Cl)Cl>[CH3:20][O:14][C:4]1[CH2:3][C@@H:2]([CH3:1])[C@H:6]([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:5]=1

Participants

4

Reactant 2

HCID 2735153Oxonium, trimethyl-, tetrafluoroborate(1-) (1:1)HCID 10750163HCID 10750163, compound

Product 1

HCID 10560088HCID 10560088, compoundYield 73.8%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of the product of Example 62 (400 mg, 2.0 mmol) in methylene chloride (25 mL) was treated with trimethyloxonium tetrafluoroborate (361 mg, 2.4 mmol) by the method of Example 3 to produce the title material (300 mg, 40%).

Sources & evidence

ORD record
ord-2f82b67687314d40ab624bb4087d1d21
Source dataset
uspto-grants-2000_01
Patent number
US06011028

Reaction notes

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