Sodium Cyanide → 2-[2-(1,3-Dioxan-2-yl)ethyl]cyclohexanone

HRID 849090Notes

Reaction equation

HRID 849090 reaction equation
[O:1]1[CH2:6][CH2:5][CH2:4][O:3][CH:2]1[CH2:7][CH2:8][C:9]1(C(OC)=O)[CH2:14][CH2:13][CH2:12][CH2:11][C:10]1=[O:15].[C-]#N.[Na+]>CS(C)=O>[O:1]1[CH2:6][CH2:5][CH2:4][O:3][CH:2]1[CH2:7][CH2:8][CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C:10]1=[O:15]

Participants

4

Reactant 2

HCID 8929Sodium CyanideHCID 18800662Methyl 1-[2-(1,3-dioxan-2-yl)ethyl]-2-oxocyclohexanecarboxylate

Product 1

HCID 107986042-[2-(1,3-Dioxan-2-yl)ethyl]cyclohexanone

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

The product of Example 108 is reacted with sodium cyanide in DMSO at 160° C. by the method of Example 103 to generate the title compound.

Sources & evidence

ORD record
ord-df313e06cac54b4fa594ab74ce8608a9
Source dataset
uspto-grants-2000_01
Patent number
US06011028

Reaction notes

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