Toluene → HCID 18800811, compound

HRID 849112Notes

Reaction equation

HRID 849112 reaction equation
[O:1]=[C:2]1[NH:8][CH:7]([CH2:9][C:10]#[N:11])[CH2:6][CH2:5][CH2:4][CH2:3]1.[F:12][C:13]([F:17])([F:16])[CH:14]=O.C1(C(Cl)=[N:25][NH2:26])C=CC=CC=1.C(N(CC)CC)C.[C:35]1(C)[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1>>[C:35]1([N:25]2[C:10]([CH2:9][CH:7]3[NH:8][C:2](=[O:1])[CH2:3][CH2:4][CH2:5][CH2:6]3)=[N:11][C:14]([C:13]([F:17])([F:16])[F:12])=[N:26]2)[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1

Participants

6

Reactant 5

HCID 1140TolueneHCID 8471TriethylamineHCID 65564TrifluoroacetaldehydeHCID 18800738HCID 18800738, compoundHCID 53412234HCID 53412234, compound

Product 1

HCID 18800811HCID 18800811, compound

Procedure

The product of Example 151 is reacted with trifluoroacetaldehyde, benzenehydrazonoyl chloride, and triethylamine in toluene by the method of R. Huisgen, Ang. Chem. Int. Ed. 1963, 2(10), 562, to generate the title compound.

Sources & evidence

ORD record
ord-03f058768647481e92f1b21df18cc78b
Source dataset
uspto-grants-2000_01
Patent number
US06011028

Reaction notes

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