反应详情

温度

80 °C

To a solution of (S)-benzyl 1-(1-(6-chloro-5-cyano-3-fluoropyridin-2-ylamino)propyl)cyclopropylcarbamate (60 mg, 0.15 mmol) in dioxane (1 mL) was added m-toluidine (19 mg, 0.18 mmol), BINAP (18.7 mg, 0.03 mmol), Pd(OAc)2 (6.7 mg, 0.03 mmol) and Cs2CO3 (146 mg, 0.45 mmol). After degassed with Argon, the mixture was heated at 80° C. for 15 h. The mixture was diluted with dioxane, precipitate was filtered off, filter cake was washed with ACN, the filtrate was concentrated and purified by column to give of (S)-benzyl 1-(1-(5-cyano-3-fluoro-6-(m-tolylamino)pyridin-2-ylamino)propyl)cyclopropylcarbamate (55 mg).

1. customAfter degassed with Argon
2. additionThe mixture was diluted with dioxane, precipitate
3. filtrationwas filtered off
4. filtrationfilter cake
5. washwas washed with ACN
6. concentrationthe filtrate was concentrated
7. custompurified by column