HCID 178418361, compound → HCID 178478657, compound

HRID 849151Notes

Reaction equation

HRID 849151 reaction equation
[ClH:1].[N+:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[CH2:11][CH:12]1[NH:18][C:17](=[NH:19])[CH2:16][CH2:15][CH2:14][CH2:13]1)([O-])=O.[H][H]>C(O)C.[Rh]>[ClH:1].[ClH:1].[NH:19]=[C:17]1[NH:18][CH:12]([CH2:11][CH:6]2[CH2:7][CH2:8][CH2:9][CH2:10][CH:5]2[NH2:2])[CH2:13][CH2:14][CH2:15][CH2:16]1

Participants

5

Reactant 2

HCID 178418361HCID 178418361, compoundHCID 178479045HCID 178479045, compound

Product 1

HCID 178478657HCID 178478657, compoundYield 48.9%

Reagents, catalysts & solvents 2

HCID 23948RhodiumCatalystHCID 702EthanolSolvent

Conditions

Temperature
60 °C

Procedure

The product of Example 270 (0.262 g, 0.9 mmol) was dissolved in ethanol, treated with 5% Rhodium on Carbon under 60 psi of Hydrogen and warmed to 60° C. to give the title product (66 mg, 0.22 mmol).

Sources & evidence

ORD record
ord-a520f14e055e4aaf94b7fdec71f943b4
Source dataset
uspto-grants-2000_01
Patent number
US06011028

Reaction notes

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