反应详情

Example 298 A) A sample of 2-benzylpyridine (Aldrich, 2.5 g, 0.015 mole), sodium amide (780 mg, 0.02 mole) and N, N-dimethylaniline (25 mL) were refluxed overnight. The contents were allowed to cool and were partitioned between ether and water. The ether layer was dried (MgSO4) and concentrated in vacuo leaving an oil. The oil was purified by chromatography. The purified material was dissolved in 1N HCl, lyophilized, and triturated with EtOAc to give 2-amino-6-benzylpyridine as a white solid.

1. temperatureto cool
2. customwere partitioned between ether and water
3. dry with materialThe ether layer was dried (MgSO4)
4. concentrationconcentrated in vacuo
5. customleaving an oil
6. customThe oil was purified by chromatography
7. dissolutionThe purified material was dissolved in 1N HCl
8. customtriturated with EtOAc