HCID 178418361, compound → HCID 178478659, compound

HRID 849162Notes

Reaction equation

HRID 849162 reaction equation
[ClH:1].Cl.[NH:3]=[C:4]1[NH:10][CH:9]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([NH2:18])=[CH:14][CH:13]=2)[CH2:8][CH2:7][CH2:6][CH2:5]1.[H][H]>CCO.[Rh]>[ClH:1].[ClH:1].[NH:3]=[C:4]1[NH:10][CH:9]([CH2:11][CH:12]2[CH2:17][CH2:16][CH:15]([NH2:18])[CH2:14][CH2:13]2)[CH2:8][CH2:7][CH2:6][CH2:5]1

Participants

5

Reactant 2

HCID 178418361HCID 178418361, compoundHCID 178478658HCID 178478658, compound

Product 1

HCID 178478659HCID 178478659, compoundYield 168.8%

Reagents, catalysts & solvents 2

HCID 23948RhodiumCatalystHCID 702EthanolSolvent

Procedure

The product of Example 274 (0.31 g, 1.2 mmol) in 30 mL of EtOH was reduced with Rhodium on carbon under 60 psi of hydrogen at 60° C. Solvent removal in vacuo followed by lyophilization in water gave 0.3 g of the title material.

Workup

  1. customSolvent removal in vacuo

Sources & evidence

ORD record
ord-aadf6ef065cc4a1fb1a3cf6e99645dc1
Source dataset
uspto-grants-2000_01
Patent number
US06011028

Reaction notes

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