3-Amino-1-propanol → 220831-12-9

HRID 849170Notes

Reaction equation

HRID 849170 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:20]2[C:19]3[CH:18]=[CH:17][CH:16]=[C:15]([O:21][C:22]([F:25])([F:24])[F:23])[C:14]=3[N:13]=[C:12](Cl)[C:11]=2[CH2:10][CH2:9]1.[NH2:27][CH2:28][CH2:29][CH2:30][OH:31]>>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:20]2[C:19]3[CH:18]=[CH:17][CH:16]=[C:15]([O:21][C:22]([F:25])([F:24])[F:23])[C:14]=3[N:13]=[C:12]([NH:27][CH2:28][CH2:29][CH2:30][OH:31])[C:11]=2[CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 90863-Amino-1-propanolHCID 11728593HCID 11728593, compound

Product 1

HCID 9823252220831-12-9

Procedure

1-(2-Methylphenyl)-4-chloro-6-trifluoromethoxy-2,3-dihydropyrrolo[3,2-c]quinoline(380 mg, 1.0 mmol) was dissolved in 3-amino-1-propanol(5 ml), then reacted at the same condition of Step 5 in the Example 1 to obtain 313 mg of desired compound as solid in 75% of yield.

Workup

  1. customreacted at the same condition of Step 5 in the Example 1

Sources & evidence

ORD record
ord-11d2aa36ee0e4b80bf045bd07a9b1f9e
Source dataset
uspto-grants-2000_01
Patent number
US06011044

Reaction notes

Loading…